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Invitrogen
NME2 Polyclonal Antibody
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NME2 Antibody (PA5-99178) in IHC (P)
Immunohistochemistry analysis of NME2 in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with NME2 polyclonal antibody (Product # PA5-99178) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-99178
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NME2(Accession P22392), corresponding to amino acid residues D98-D148.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NM23.
靶标信息
Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2.7.13.3; c-myc purine-binding transcription factor PUF; c-myc transcription factor; epididymis secretory sperm binding protein Li 155an; expressed in non-metastatic cells 2; expressed in non-metastatic cells 2 protein; HEL-S-155an; histidine protein kinase NDKB; NDK B; NDP kinase alpha; NDP kinase B; nm23-H2S product (putative NDP kinase); putative; NME2; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphoshate kinase 2; nucleoside diphosphate kinases 2; nucleoside-diphosphate kinase 2; nucleotide diphosphate kinase B; P18; unnamed protein product
基因别名: NDK2; NDKB; NDPK B; NDPK-B; NDPK2; NDPKB; nm23-2; NM23-H2; nm23-M2; NM23B; p18-12d; PUF
UniProt ID: (Human) P22392, (Mouse) Q01768, (Rat) P19804
Entrez Gene ID: (Human) 4831, (Mouse) 18103, (Rat) 83782
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DNA binding
nuclease activity
nucleoside diphosphate kinase activity
protein histidine kinase activity
protein binding
kinase activity
GDP binding
identical protein binding
G-quadruplex DNA binding
protein serine/threonine kinase activity
fatty acid binding
intermediate filament binding
enzyme binding
coenzyme A binding
heterocyclic compound binding
GTP biosynthetic process
UTP biosynthetic process
dTMP biosynthetic process
CTP biosynthetic process
integrin-mediated signaling pathway
nucleoside triphosphate biosynthetic process
regulation of fatty acid biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell adhesion
nucleotide biosynthetic process
negative regulation of apoptotic process
positive regulation of keratinocyte differentiation
regulation of epidermis development
ITP biosynthetic process
positive regulation of epithelial cell proliferation
positive regulation of DNA-templated transcription, initiation
negative regulation of myeloid leukocyte differentiation
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of neuron projection development
cellular response to oxidative stress
protein autophosphorylation
response to growth hormone
cellular response to glucose stimulus
cellular response to fatty acid
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