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Invitrogen
NME3 Polyclonal Antibody
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NME3 Antibody (PA5-29749) in ICC/IF
Immunofluorescent analysis of nm23-H3 showing staining in the mitochondria of HeLa cells. HeLa cells were fixed in 2% paraformaldehyde/culture medium at 37°C for 30 min and stained using a nm23-H3 polyclonal antibody (Product # PA5-29749) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-29749
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 163 of Human nm23-H3
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PA5-29749 targets nm23-H3 in IF and ICC applications and shows reactivity with Human samples.
The PA5-29749 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 163 of Human nm23-H3.
靶标信息
NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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