Proteintech

NO66/C14orf169 Polyclonal Antibody

Name: NO66\/C14orf169 Polyclonal Antibody
Brand: Proteintech
SKU: 22842-1-AP

查看其他7个NO66抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (4)

NO66/C14orf169 Antibody in Western Blot (WB)

图: 1 / 4

NO66/C14orf169 Antibody (22842-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 22842-1-AP) NO66/C14orf169 antibody at dilution of 1:3,000 incubated at room temperature for 1.5 hours.

NO66/C14orf169 Antibody in Immunoprecipitation (IP)

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Immunogen image

Immunogen Image NO66/C14orf169 Polyclonal Antibody

产品信息

22842-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

NO66/C14orf169 Fusion Protein Ag18721 (296-640 aa encoded by BC011350)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.21 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: LRLLCPQAF STTVWQFLAV LQEQFGSMAG SNVYLTPPNS QGFAPHYDDI EAFVLQLEGR KLWRVYRPRA PTEELALTSS PNFSQDDLGE PVLQTVLEPG DLLYFPRGFI HQAECQDGVH SLHLTLSTYQ RNTWGDFLEA ILPLAVQAAM EENVEFRRGL PRDFMDYMGA QHSDSKDPRR TAFMEKVRVL VARLGHFAPV DAVADQRAKD FIHDSLPPVL TDRERALSVY GLPIRWEAGE PVNVGAQLTT ETEVHMLQDG IARLVGEGGH LFLYYTVENS RVYHLEEPKC LEIYPQQADA MELLLGSYPE FVRVGDLPCD SVEDQLSLAT TLYDKGLLLT KMPLAL (296-640 aa encoded by BC011350)

靶标信息

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 60S ribosomal protein L8 histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; FLJ21802; histone lysine demethylase NO66; hsNO66; lysine-specific demethylase NO66; MYC-associated protein with JmjC domain; Nucleolar protein 66; Ribosomal oxygenase 1; Ribosomal oxygenase NO66; ROX; up-regulated in lung cancer 2

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基因别名: C14orf169; hsNO66; MAPJD; NO66; RIOX1; ROX; URLC2

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UniProt ID: (Human) Q9H6W3

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Entrez Gene ID: (Human) 79697

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功能

iron ion binding protein binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors histone demethylase activity (H3-K4 specific) histone demethylase activity (H3-K36 specific)

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