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Invitrogen
NOD3 Polyclonal Antibody
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图: 1 / 2
NOD3 Antibody (PA5-115658) in ICC/IF
Immunocytochemistry analysis of NOD3 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115658) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115658
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NLRC3(Accession Q7RTR2), corresponding to amino acid residues L1026-M1065.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NLRC3.
靶标信息
NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CARD15-like protein; caterpillar 16.2; Caterpiller 16.2; Caterpiller protein 16.2; CLR16.2; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NLR family, CARD domain containing 3, pseudogene 1; Nucleotide-binding oligomerization domain protein 3; Protein NLRC3
基因别名: CLR16.2; D230007K08Rik; mFLJ00348; NLRC3; Nlrc3-ps1; NOD3; RGD1304902
UniProt ID: (Mouse) Q5DU56
Entrez Gene ID: (Rat) 287070, (Mouse) 268857
I-kappaB kinase/NF-kappaB signaling
regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
response to lipopolysaccharide
T cell activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
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