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Recommended positive controls: IMR32, U87-MG, mouse brain.
Predicted reactivity: Mouse (89%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Nrap; Nucleolar protein 6; nucleolar protein 6 (RNA-associated); nucleolar protein family 6 (RNA-associated); Nucleolar RNA-associated protein
基因别名: AA410091; bA311H10.1; NOL6; NRAP; UTP22
UniProt ID: (Human) Q9H6R4, (Mouse) Q8R5K4
Entrez Gene ID: (Human) 65083, (Mouse) 230082