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7TM Antibodies
NOP, Nociceptin/Orphanin FQ Receptor Polyclonal Antibody
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NOP, Nociceptin/Orphanin FQ Receptor Antibody (7TM0320N) in WB
Validation of the Nociceptin/Orphanin FQ Receptor in transfected HEK293 cells. Native HEK293 cells (MOCK) or HEK293 cells stably expressing the Nociceptin/Orphanin FQ Receptor (NOP) were lysed and immunoblotted with the phosphorylation-independent anti-NOP antibody (7TM0320N-WB) at a dilution of 1:1,000.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
7TM0320N
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide presents carboxyl - terminal tail of human NOP.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: K3 opiate receptor; Kappa-type 3 opioid receptor; KOR-3; LC132 Receptor-Like; N/OFQ receptor; Nociceptin receptor; nociceptin receptor ORL1; nociceptin/ orphaninFQ receptor; opioid receptor-like 1; OPPRL1; ORGC; Orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR1
基因别名: KOR-3; KOR3; LC132; MOR-C; morc; OFQR; OOR; Oprl; OPRL1; ORGC; ORL1; XOR1
UniProt ID: (Mouse) P35377, (Rat) P35370
Entrez Gene ID: (Mouse) 18389, (Rat) 29256
positive regulation of protein phosphorylation
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
chemical synaptic transmission
behavior
sensory perception of pain
regulation of cAMP biosynthetic process
negative regulation of cAMP biosynthetic process
positive regulation of urine volume
opioid receptor signaling pathway
eating behavior
negative regulation of blood pressure
regulation of sensory perception of pain
positive regulation of gastric acid secretion
negative regulation of voltage-gated calcium channel activity
positive regulation of sensory perception of pain
regulation of locomotor rhythm
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