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Invitrogen
NOX4 Polyclonal Antibody
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NOX4 Antibody (PA5-31914) in ICC/IF
NOX4 Polyclonal Antibody detects NOX4 protein at cytoplasm by immunofluorescent analysis. Sample: A431 cells were fixed in ice-cold MeOH for 5 min. Green: NOX4 protein stained by NOX4 Polyclonal Antibody (Product # PA5-31914) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-31914
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 252 and 564 of Human NOX4
偶联物
形式
Liquid
浓度
0.96 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PA5-31914 targets NOX4 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-31914 immunogen is recombinant protein fragment corresponding to a region within amino acids 252 and 564 of Human NOX4.
靶标信息
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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