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Peptide sequence: MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL
Sequence homology: Cow: 93%; Dog: 93%; Human: 100%; Mouse: 93%; Rat: 93%; Yeast: 83%
The discovery of NPDC-1 (neuronal proliferation, differentiation and control protein 1) was the result of a study of genes that were preferentially expressed in immortalized neural precursor cell lines at the onset of contact inhibition of proliferation and subsequent differentiation. It was further found that transfection of transformed cells with NPDC-1 led to increased doubling times and suppression of many characteristics of transformation. NPDC-1 is differentially expressed in brain and lung and has been shown to interact directly with the transcription factor E2F-1 as well as D-type cyclins and cdk2. NPDC-1 has been identified as a modulator of transcriptiona levents mediated by retinoic acid and the protein level and activity of NPDC-1 have been shown to be regulated by phosphorylation mediated proteasomal degradation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZP586J0523; Neural proliferation differentiation and control protein 1; neural proliferation, differentiation and control, 1; NPDC-1; RP23-47P18.6
基因别名: CAB; CAB-; CAB-1; CAB1; NPDC-1; NPDC1
UniProt ID: (Human) Q9NQX5
Entrez Gene ID: (Human) 56654
