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Invitrogen
NR5A2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-110041
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 300-541 of human NR5A2 (NP_9955821)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.81 mg/mL
规格
181 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SIPHLILELL KCEPDEPQVQ AKIMAYLQQE QANRSKHEKL STFGLMCKMA DQTLFSIVEW ARSSIFFREL KVDDQMKLLQ NCWSELLILD HIYRQVVHGK EGSIFLVTGQ QVDYSIIASQ AGATLNNLMS HAQELVAKLR SLQFDQREFV CLKFLVLFSL DVKNLENFQL VEGVQEQVNA ALLDYTMCNY PQQTEKFGQL LLRLPEIRAI SMQAEEYLYY KHLNGDVPYN NLLIEMLHAK RA
靶标信息
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-1-fetoprotein transcription factor; B1-binding factor; CYP7A promoter-binding factor; Fetoprotein transcription factor; FTZ F1; FTZ F1beta; FTZ-F1 beta; FTZ-F1 beta2 protein; hB1F; hB1F 2; Hepatocytic transcription factor; live; Liver receptor homolog 1; LRH-1; mFTF; Nuclear receptor subfamily 5 group A member 2
基因别名: AU020803; B1F; CPF; D1Ertd308e; FTF; LRH-1; Lrh1; NR5A2; UF2-H3B
UniProt ID: (Rat) Q9QWM1, (Mouse) P45448
Entrez Gene ID: (Rat) 60349, (Mouse) 26424
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
phospholipid binding
zinc ion binding
lipid binding
sequence-specific DNA binding
transcription regulatory region DNA binding
metal ion binding
C4 zinc finger nuclear receptor
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
bile acid metabolic process
intracellular receptor signaling pathway
epithelial cell differentiation
regulation of cell proliferation
cholesterol homeostasis
steroid hormone mediated signaling pathway
positive regulation of viral genome replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
pancreas morphogenesis
regulation of transcription from RNA polymerase II promoter
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