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Invitrogen
NRBF2 Recombinant Rabbit Monoclonal Antibody (15H7L3)
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NRBF2 Antibody (702920) in WB
Western blot analysis was performed on modified whole cell extracts (1% SDS) (30 µg lysate) of MCF7 (Lane 1), MDA-MB-231 (Lane 4), T-47D (Lane 5), A-375 (Lane 6), Hep G2 (Lane 7) and tissue extracts of Mouse Brain (Lane 2) and Rat Brain (Lane 3). The blot was probed with Anti-NRBF2 Recombinant Rabbit Monoclonal Antibody (Product # 702920, 1:5000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 36 kDa band co... View More
产品信息
702920
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
15H7L3
抗原
Protein corresponding to human NRBF2 [aa4-aa90]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Sheep, Bovine, Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
NRBF2 (nuclear receptor-binding factor 2) modulates transcriptional activation by target nuclear receptors. It is involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). NRBF2 stabilizes the PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Comodulator of PPAR and RXR; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; NRBF-2; nuclear receptor binding factor-2; Nuclear receptor-binding factor 2
基因别名: COPR; COPR1; COPR2; NRBF-2; NRBF2
UniProt ID: (Human) Q96F24, (Rat) Q9QYK3, (Mouse) Q8VCQ3
Entrez Gene ID: (Human) 29982, (Rat) 58839, (Mouse) 641340
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
autophagy
regulation of autophagy
response to endoplasmic reticulum stress
regulation of lipid kinase activity
transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
regulation of transcription from RNA polymerase II promoter
