Invitrogen

NRG4 Recombinant Rabbit Monoclonal Antibody (001)

Name: NRG4 Recombinant Rabbit Monoclonal Antibody (001)
Brand: Invitrogen
SKU: MA5-30717

查看其他10个NRG4抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image NRG4 Recombinant Rabbit Monoclonal Antibody (001)

产品信息

MA5-30717

应用

建议稀释比

已发表文章

酶联免疫吸附实验 (ELISA)

1:5,000-1:10,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

001

抗原

Recombinant Human NRG4 Protein

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2786408

产品详细信息

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This antibody has specificity for Human NRG4.

靶标信息

Neuregulin 4 (NRG4) is a member of the Neuregulin family serving as a ligand for the epidermal growth factor receptor (EGFR) family, specifically interacting with ERBB4. This gene is primarily expressed in brown adipose tissue and liver, where it plays a pivotal role in metabolic regulation. NRG4 acts as a critical signaling molecule in adipose tissue, promoting systemic glucose homeostasis and energy expenditure while inhibiting hepatic lipogenesis, thereby contributing to protection against diet-induced obesity and insulin resistance. Moreover, NRG4 expression is inversely correlated with adiposity and positively correlated with insulin sensitivity, suggesting its potential role in metabolic homeostasis. Studies reveal that NRG4's interaction with ERBB4 stimulates specific cellular pathways, which can impact hepatic gluconeogenesis, underscoring its importance in glucose metabolism. Additionally, NRG4 has been linked to breast cancer progression, where it contributes to tumor cell survival through signaling pathways involving receptor tyrosine kinases. Due to its significant involvement in metabolic pathways and cancer biology, NRG4 is considered a promising target for therapeutic intervention in metabolic disorders and certain cancers.

仅用于科研。不用于诊断过程。未经明确授权不得转售。