Invitrogen

NTF3 Polyclonal Antibody

查看其他16个NTF3抗体

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NTF3 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of NTF3 in paraffin-embedded human esophagus using NTF3 Polyclonal Antibody (Product # PA5-96235) at a dilution of 1:100.

NTF3 Antibody in Western Blot (WB) — Western Blot analysis of NTF3 in extracts of mouse heart using NTF3 Polyclonal Antibody (Product # PA5-96235) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

产品信息

PA5-96235

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化（石蜡） (IHC (P))

1:100 - 1:200

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A recombinant fusion protein containing a sequence corresponding to amino acids 19-257 of human NTF3.

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.9 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2808037

产品详细信息

Positive Samples: Mouse heart

靶标信息

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HDNF; Nerve growth factor 2; Neurotrophic factor; Neurotrophin-3; NGF-2; NT-3

基因别名: AI316846; AI835689; HDNF; NGF-2; NGF2; NT-3; NT3; Ntf-3; NTF3

UniProt ID: (Human) P20783, (Mouse) P20181

Entrez Gene ID: (Human) 4908, (Mouse) 18205

分子生物学功能: neurotrophic factor

activation of MAPK activity positive regulation of receptor internalization signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell-cell signaling nervous system development positive regulation of cell proliferation positive regulation of cell migration activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation myelination regulation of apoptotic process negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of glial cell differentiation neuron projection morphogenesis positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation modulation of synaptic transmission positive chemotaxis induction of positive chemotaxis activation of GTPase activity positive regulation of actin cytoskeleton reorganization neuromuscular synaptic transmission glial cell fate determination axon guidance brain development peripheral nervous system development epidermis development nerve development mechanoreceptor differentiation regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter enteric nervous system development neuron development generation of neurons smooth muscle cell differentiation

参与通路

receptor binding neurotrophin p75 receptor binding protein binding growth factor activity chemoattractant activity nerve growth factor binding neurotrophin receptor binding