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Proteintech
NTHL1 Polyclonal Antibody
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产品信息
14918-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NTHL1 Fusion Protein Ag6734 (2-305 aa encoded by BC000391)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MTALSARML TRSRSLGPGA GPRGCREEPG PLRRREAAAE ARKSHSPVKR PRKAQRLRVA YEGSDSEKGE GAEPLKVPVW EPQDWQQQLV NIRAMRNKKD APVDHLGTEH CYDSSAPPKV RRYQVLLSLM LSSQTKDQVT AGAMQRLRAR GLTVDSILQT DDATLGKLIY PVGFWRSKVK YIKQTSAILQ QHYGGDIPAS VAELVALPGV GPKMAHLAMA VAWGTVSGIA VDTHVHRIAN RLRWTKKATK SPEETRAALE EWLPRELWHE INGLLVGFGQ QTCLPVHPRC HACLNQALCP AAQGL (2-305 aa encoded by BC000391)
靶标信息
Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites.A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; Endonuclease III-like protein 1; hNTH1; nth endonuclease III-like 1; NTHL 1; OCTS 3; thymine glycol DNA glycosylase/AP lyase
基因别名: FAP3; hNTH1; NTH1; NTHL1; OCTS3
UniProt ID: (Human) P78549, (Mouse) O35980
Entrez Gene ID: (Human) 4913, (Mouse) 18207, (Rat) 29541
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
double-stranded DNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
endonuclease activity
protein binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
DNA N-glycosylase activity
metal ion binding
4 iron, 4 sulfur cluster binding
purine-specific mismatch base pair DNA N-glycosylase activity
DNA binding
catalytic activity
uracil DNA N-glycosylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
lyase activity
single-strand selective uracil DNA N-glycosylase activity
DNA-3-methylbase glycosylase activity
iron-sulfur cluster binding
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
positive regulation of defense response to virus by host
base-excision repair, AP site formation
nucleotide-excision repair, DNA incision, 5'-to lesion
depyrimidination
mitophagy in response to mitochondrial depolarization
xenophagy
DNA repair
base-excision repair
cellular response to DNA damage stimulus
metabolic process
DNA catabolic process, endonucleolytic
