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Invitrogen
NTN3 Polyclonal Antibody
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产品信息
PA5-62249
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: CVPGLVNAAL GREVLASSTC GRPATRACDA SDPRRAHSPA LLTSPGGTAS PLCWRSESLP RAPLNVTLTV PLGKAFELVF V
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 83%.
靶标信息
Netrin-3 (NTN3) is a gene located on chromosome 16q22.1, encoding a protein that belongs to the netrin family of secreted molecules crucial for axon guidance and cell signaling in nervous system development. NTN3 is primarily expressed in the central nervous system, where it functions as a guidance cue for developing neurons, influencing processes such as axon attraction or repulsion and the establishment of neural networks. The protein interacts with specific receptors on neuronal growth cones to mediate directional movement and synapse formation. Beyond its role in neural development, NTN3 is involved in tissue morphogenesis and cellular migration in other physiological contexts. Aberrant expression or mutations in NTN3 can lead to developmental disorders and neurodegenerative conditions due to impaired neural pathway formation. Research into NTN3 continues to explore its therapeutic potential for enhancing neural repair and regeneration in pathological states.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Netrin-2, chicken, homolog of, like; Netrin-2-like protein; Netrin-3
基因别名: NTN2L; NTN3
UniProt ID: (Human) O00634
Entrez Gene ID: (Human) 4917
