This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
The target sequence has 90% sequence homology with rat.
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
蛋白别名: h-Numb; m-Nb; m-numb; mnb; numb homolog; Numb variant 1; Numb variant 2; Protein numb homolog; Protein S171; PTB domain protein
基因别名: c14_5527; C14orf41; Nb; NUMB; S171
分子生物学功能: scaffold/adaptor protein