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Invitrogen
NUP62 Monoclonal Antibody (RL1)
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NUP62 Antibody (MA1-071) in IHC (P)
Immunohistochemistry was performed on normal biopsies of deparaffinized Rat lymph node tissue. To expose target proteins, heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes. Following antigen retrieval tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature. Tissues were then probed at a dilution of 1:200 with a mouse monoclonal a... View More
产品信息
MA1-071
应用
建议稀释比
已发表文章
产品规格
种属反应
Amphibian,
Rat,
Yeast
已发表种属
Human,
Invertebrate,
Mouse,
Rat,
Yeast
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
RL1
抗原
Pore complex-lamina fraction purified from rat liver nuclear envelopes.
偶联物
形式
Liquid
纯化类型
PEG precipitation
保存液
PBS
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-071 detects nuclear pore-O-linked glycoprotein from rat, amphibian and yeast.
MA1-071 has been successfully used in Western blot, immunofluorescence and immunoprecipitation procedures. By Western blot, this antibody detects up to eight different proteins from the nuclear pore complex (NPC) of approximately 210, 180, 145, 100, 63, 58, 54 and 45 kDa. Immunofluorescence staining of NPC O-linked glycoproteins with MA1-071 results in exclusive labeling of the NPC proteins on a wide variety of mammalian cells as well as S. cerevisiae and Xenopus. Labeling occurs exclusively at the NPC with most of the labeling at the cytoplasmic and nucleoplasmic margins.
Microinjected MA1-071 inhibits both protein import and RNA export in Xenopus oocytes.
The MA1-071 immunogen is pore complex-lamina fraction purified from rat liver nuclear envelopes.
靶标信息
SDS3 is a subunit of the histone deacetylase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 62 kDa nucleoporin; DKFZp547L134; FLJ20822; FLJ43869; MGC841; nuclear pore glycoprotein 62; Nuclear pore glycoprotein p62; Nucleoporin Nup62; nucleoporin p62
基因别名: Np62; Nup62
UniProt ID: (Rat) P17955
Entrez Gene ID: (Rat) 65274
transcription, DNA-templated
cell surface receptor signaling pathway
cell aging
cell death
negative regulation of cell proliferation
protein transport
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAP kinase activity
positive regulation of transcription, DNA-templated
negative regulation of Ras protein signal transduction
mRNA transport
