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Invitrogen
NUR77 Polyclonal Antibody
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产品信息
PA1-29841
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide TSTKARSGAPGGSEGR, corresponding to amino acids 251-266 of Human NUR77.
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
PA1-29841 detects NUR77 from human and mouse samples. Expected to cross react with rat samples due to 87% sequence identity.
PA1-29841 has been successfully used in Western blot applications. Positive controls of Molt4 or NIH3T3 whole cell lysate suggested.
The PA1-29841 immunogen is synthetic peptide: TSTKARSGAPGGSEGR, corresponding to amino acids 251-266 of Human NUR77.
Store at 4°C short term. For extended storage, aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
靶标信息
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NGFI-B-alpha is expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung and prostate. Its expression is induced in response to various stress stimuli and growth factors. The encoded protein acts as a nuclear transcription factor involved in mediating apoptotic signaling in thymocytes and tumor cells, as well as having a role in signaling in the hypothalamic-pituitary axis. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this NR4A1. Variant (3), also known as TRC beta, contains multiple differences compared to variant 1. The resulting isoform b contains a shorter and distinct C-terminus compared to isoform a. RXR has been shown to be a partner for NR4A1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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