Search
Fabgennix
NeuroD1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
产品信息
NDF1-101AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids within region 300-356 on human Neurogenic differentiation factor 1 protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer with 20% glycerol, 0.5% BSA
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Quantity: 100 µg IgG per vial
靶标信息
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: basic helix-loop-helix factor 1; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; beta-cell E-box transcriptional activator 2; BHF-1; BHF1; class A basic helix-loop-helix protein 3; neuro d1; neurogenic differentiation 1; neurogenic helix-loop-helix protein NEUROD; neurogenic helix-loop-helix protein NEUROD; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; unnamed protein product
基因别名: BETA2; BHF-1; bHLHa3; MODY6; Nd1; NEUROD; T2D
UniProt ID: (Human) Q13562, (Mouse) Q60867, (Rat) Q64289
Entrez Gene ID: (Human) 4760, (Mouse) 18012, (Rat) 29458
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
E-box binding
sequence-specific double-stranded DNA binding
double-stranded DNA binding
pancreatic A cell fate commitment
pancreatic PP cell fate commitment
regulation of transcription, DNA-templated
nucleocytoplasmic transport
nervous system development
central nervous system development
sensory organ development
response to glucose
anterior/posterior pattern specification
dentate gyrus development
cerebellum development
signal transduction involved in regulation of gene expression
insulin secretion
hindbrain development
endocrine pancreas development
positive regulation of insulin secretion
amacrine cell differentiation
enteroendocrine cell differentiation
glucose homeostasis
camera-type eye development
positive regulation of apoptotic process
cell fate commitment
positive regulation of cell differentiation
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
embryonic organ morphogenesis
inner ear development
regulation of intestinal epithelial structure maintenance
axon development
cellular response to glucose stimulus
cellular response to glucocorticoid stimulus
negative regulation of type B pancreatic cell apoptotic process
neurogenesis
regulation of insulin secretion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
