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Alomone Labs, LTD
Neuronal Pentraxin 2 (NPTX2) Polyclonal Antibody
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Neuronal Pentraxin 2 (NPTX2) Antibody (ANR-192-200UL) in IHC (F)
Expression of NPTX2 in mouse cortex. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Anti-Neuronal Pentraxin 2 (NPTX2) Antibody (#ANR-192) (1:300), followed by goat anti-rabbit-AlexaFluor-488. A. NPTX2 immunoreactivity (green) appears in cells of the upper layer (vertical arrows) and in cells of a deeper layer (horizontal arrow). B. Pre-incubation of the antibody with Neuro... View More
产品信息
ANR-192-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide RLEPNSIDPENITE, corresponding to amino acid residues 57-70 of rat TrkB. Extracellular, N-terminus.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
规格
160 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: RLEPNSIDPENITE
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: apexin; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; Neuronal pentraxin II; Neuronal pentraxin-2; NP-II; NP2
基因别名: NARP; NP-II; NP2; NPTX2
UniProt ID: (Human) P47972, (Mouse) O70340
Entrez Gene ID: (Human) 4885, (Rat) 288475, (Mouse) 53324
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