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Invitrogen
Nicotine Recombinant Mouse Monoclonal Antibody (2B1)
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Nicotine Antibody (MA566402) in SDS-PAGE
SDS-PAGE characterization of Nicotine under reducing conditions. Lane M: Protein marker (kDa); Lane NCT: Purified Nicotine Recombinant Monoclonal (Product # MA566402). Nicotine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-298.
产品信息
MA566402
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2B1
抗原
Conjugate of NCT hapten and KLH.
偶联物
形式
Liquid
浓度
8.8 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Nicotine is an alkaloid found primarily in the nightshade family of plants, notably in tobacco leaves, and is recognized for its potent psychoactive effects as well as its addictive properties. Structurally, nicotine is composed of a pyridine ring connected to a pyrrolidine ring, which facilitates its ability to act as an agonist at nicotinic acetylcholine receptors in the brain. This interaction leads to increased release of neurotransmitters such as dopamine, contributing to feelings of pleasure and reward, alongside heightened alertness and cognitive function. While nicotine has been utilized historically in medicine and as a natural pesticide, its primary association today is with smoking and tobacco products, significantly impacting public health due to its role in addiction and related diseases such as lung cancer and cardiovascular disorders. Research continues into nicotine's pharmacokinetics, effects on neural pathways, and potential therapeutic applications, particularly in smoking cessation and neurodegenerative disease contexts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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