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Proteintech
Noggin Monoclonal Antibody (2A11C1), NeutraKine®
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Noggin Antibody (69010-1-IG) in Flow
1X10^6 PC-3 cells were stained with 0.5 µg NeutraKine® Noggin antibody (69010-1-Ig, Clone: 2A11C1) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (green), or stained with 0.5 µg isotype control and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (black). Cells were fixed with 4% PFA and permeabilized with 0.1% Triton X-100.
产品信息
69010-1-IG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2A11C1
抗原
NeutraKine Noggin fusion protein HZ-1118
偶联物
形式
Lyophilized
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Reconstitute with water to the desired concentration.
Lyophilized antibodies are stable for 1 year from the date of purchase if stored between -20 to -80°C. Upon reconstitution, we recommend that the solution be stored at 4°C (short- term) or at -20 to -80°Cfor long term. Repeated freeze-thaw cycles should be avoided with reconstituted products.
Aliquoting is unnecessary for -20°C storage.
靶标信息
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Noggin; Noggin precursor; symphalangism 1 (proximal)
基因别名: NOG; SYM1; SYNS1; SYNS1A
UniProt ID: (Human) Q13253
Entrez Gene ID: (Human) 9241
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
in utero embryonic development
endoderm formation
mesoderm formation
epithelial to mesenchymal transition
neural plate morphogenesis
neural tube closure
nervous system development
motor neuron axon guidance
dorsal/ventral pattern formation
spinal cord development
cell differentiation in hindbrain
pituitary gland development
negative regulation of cell migration
BMP signaling pathway
negative regulation of BMP signaling pathway
somatic stem cell population maintenance
wound healing
middle ear morphogenesis
embryonic digit morphogenesis
regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
axial mesoderm development
notochord morphogenesis
embryonic skeletal system development
negative regulation of astrocyte differentiation
positive regulation of epithelial cell proliferation
cartilage development
negative regulation of cardiac muscle cell proliferation
limb development
embryonic skeletal joint morphogenesis
negative regulation of cytokine activity
face morphogenesis
negative regulation of pathway-restricted SMAD protein phosphorylation
lung morphogenesis
prostatic bud formation
ureteric bud formation
fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of cartilage development
somite development
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of glomerulus development
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of apoptotic signaling pathway
