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The antibody detects endogenous levels of total OLFM3 protein.
OLFM3 (olfactomedin 3), also known as NOE3, is a 478 amino acid protein that interacts with myocilin. Myocilin is an extracellular protein that plays a key role in the actomyosin system and is responsible for controlling intraocular pressure. OLFM3 is a secreted protein that contains an olfactomedin-like (OLF) domain, an approximately 260 amino acid motif commonly found in secreted glycoproteins. OLFM3 localizes to the Golgi apparatus of the cell and is highly expressed in both eye and brain tissue. Mutations in the gene that encodes OLFM3 may cause severe glaucoma, a condition in which increased intraocular pressure within the eyeball causes loss of eye sight.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Protein Aliases: Noelin-3; olfactomedin related ER localized protein 3; Olfactomedin-3; Optimedin
Gene Aliases: B230206G02Rik; NOE3; NOELIN3; OLFM3; OPTIMEDIN; UNQ1924/PRO4399
UniProt ID: (Human) Q96PB7, (Mouse) Q8R4K4
Entrez Gene ID: (Human) 118427, (Mouse) 229759
Molecular Function:
structural protein
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