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Proteintech
OLIG2 Monoclonal Antibody (1E8C5)
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产品信息
66513-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
1E8C5
抗原
OLIG2 Fusion Protein Ag18838 (1-323 aa encoded by BC047511)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDSDASLVS SRPSSPEPDD LFLPARSKGS SGSAFTGGTV SSSTPSDCPP ELSAELRGAM GSAGAHPGDK LGGSGFKSSS SSTSSSTSSA AASSTKKDKK QMTEPELQQL RLKINSRERK RMHDLNIAMD GLREVMPYAH GPSVRKLSKI TTLLLARNYI LMLTNSLEEM KRLVSEIYGG HHAGFHPSAC GGLAHSAPLP AATAHPAAAA HAAHHPAVHH PILPPAAAAA AAAAAAAAVS SASLPGSGLP SVGSIRPPHG LLKSPSAAAA APLGGGGGGS GASGGFQHWG GMPCPCSMCQ VPPPHHHVSA MGAGSLPRLT SDAK (1-323 aa encoded by BC047511)
靶标信息
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: basic domain, helix-loop-helix protein, class B, 1; Basic helix loop helix protein class B1 (bHLHB1); basic helix-loop-helix protein 19 (bHLHe19); bHLHb1; bHLHe19; Class B basic helix-loop-helix protein 1; Class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; olig-2; Oligo2; Oligo2 antibody; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein 2; Protein kinase C-binding protein 2 (PRKCBP2); Protein kinase C-binding protein RACK17
基因别名: AI604895; BHLHB1; BHLHE19; Olg-2; OLIG2; OLIGO2; PRKCBP2; RACK17; RK17
UniProt ID: (Human) Q13516, (Mouse) Q9EQW6
Entrez Gene ID: (Human) 10215, (Mouse) 50913, (Rat) 304103
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein homodimerization activity
HMG box domain binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
spinal cord motor neuron differentiation
spinal cord oligodendrocyte cell fate specification
thalamus development
myelination
negative regulation of neuron differentiation
neuron fate commitment
positive regulation of oligodendrocyte differentiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
nervous system development
spinal cord oligodendrocyte cell differentiation
oligodendrocyte differentiation
