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Abnova
OPRL1 Monoclonal Antibody (2A11)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00004987-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2A11
抗原
OPRL1 (AAH38433, 110 a.a. approximately 212 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: DILLGFWPFG NALCKTVIAI DYYNMFTSTF TLTAMSVDRY VAICHPIRAL DVRTSSKAQA VNVAIWALAS VVGVPVAIMG SAQVEDEEIE CLVEIPTPQD YWG
靶标信息
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein-coupled receptor; G-protein coupled receptor; kappa-type 3 opioid receptor; kappa3-related opioid receptor; LC132 Receptor-Like; nociceptin/orphanin FQ receptor; opiate receptor-like 1; opioid receptor; OPPRL1; OPRL1; ORL1; orphanin FQ receptor; splice variant of KOR-3 gene
基因别名: KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL; ORL1; PNOCR
UniProt ID: (Human) P41146
Entrez Gene ID: (Human) 4987
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
neuron-neuron synaptic transmission
sensory perception
sensory perception of pain
calcium-mediated signaling
opioid receptor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
