Invitrogen

OPRM1 Polyclonal Antibody

6个已发表图片
6 篇参考文献
查看其他27个OPRM1抗体

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说明书
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问题与答案
技术支持

产品信息

44-308G

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看3篇已发表文章 3篇已发表文章

免疫组化 (IHC)

-
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:250
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其他PubMed (Misc)

-
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产品规格

种属反应

Human, Mouse, Rabbit, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

The antiserum was produced against a chemically synthesized peptide derived from an internal region of the human m-opioid receptor.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533629

靶标信息

The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: hMOP; KIAA0403; M-OR-1; MOP; MOP receptor; MOR-1; MOR-1C; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant mMOR-1Z; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; Mu-type opioid receptor; MUOR1; Opioid mu receptor; Opioid Receptor; Opioid receptor B; opioid receptor, mu 1; OTTHUMP00000017463

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基因别名: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; MORA; muOR; OPRM; OPRM1; Oprrm1; Ror-b

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UniProt ID: (Human) P35372, (Rat) P33535, (Mouse) P42866

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Entrez Gene ID: (Human) 4988, (Rat) 25601, (Mouse) 18390

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功能
G-protein alpha-subunit binding G-protein coupled receptor activity beta-endorphin receptor activity voltage-gated calcium channel activity protein binding protein C-terminus binding protein domain specific binding filamin binding G-protein beta-subunit binding morphine receptor activity neuropeptide binding opioid receptor activity signal transducer activity G-protein coupled receptor transmembrane signal receptor
参与通路
acute inflammatory response to antigenic stimulus G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating dopamine receptor signaling pathway negative regulation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway chemical synaptic transmission sensory perception locomotory behavior negative regulation of cell proliferation response to radiation sensory perception of pain adenylate cyclase-inhibiting opioid receptor signaling pathway response to food positive regulation of appetite response to lipopolysaccharide cellular response to stress wound healing response to cocaine eating behavior estrous cycle behavioral response to ethanol positive regulation of neurogenesis regulation of sensory perception of pain excitatory postsynaptic potential negative regulation of Wnt protein secretion positive regulation of ERK1 and ERK2 cascade calcium ion transmembrane transport response to growth factor cellular response to morphine regulation of N-methyl-D-aspartate selective glutamate receptor activity immune response G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration opioid receptor signaling pathway response to morphine positive regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling negative regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process response to ethanol negative regulation of cytosolic calcium ion concentration signal transduction negative regulation of cAMP biosynthetic process
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