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This target displays homology in the following species: Dog: 83%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4; oligosaccharyltransferase 4 homolog; oligosaccharyltransferase complex subunit 4 (non-catalytic)
基因别名: OST4
UniProt ID: (Human) P0C6T2
Entrez Gene ID: (Human) 100128731
分子生物学功能: protein modifying enzyme