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Invitrogen
OTX2 Polyclonal Antibody
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OTX2 Antibody (PA5-115699) in IHC (P)
Immunohistochemistry analysis of OTX2 in rat brain tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115699) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115699
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human OTX2(Accession P32243), corresponding to amino acid residues D200-F250.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Otx2.
靶标信息
OTX2 is a 289 amino acid containing protein encoding a member of the bicoid sub-family of homeodomain-containing transcription factors. It has two known alternative splice variants with distinct isoforms though presence of other isoforms cannot be excluded. The protein is an early marker of endodermal differentiation of embryonic stem cells and may play a role in the development of the brain and the sensory organs. The protein may bind to BCD target sequence (BTS): 5-'TCTAATCCC-3'. Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeobox Otx2; Homeobox protein OTX2; Orthodenticle homolog 2; OTX
基因别名: E130306E05Rik; OTX2
Entrez Gene ID: (Rat) 305858, (Mouse) 18424
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
protein heterodimerization activity
homeodomain transcription factor
regulation of transcription, DNA-templated
multicellular organism development
cell fate specification
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein complex assembly
axon guidance
central nervous system development
endoderm development
organ morphogenesis
anterior/posterior pattern specification
dorsal/ventral pattern formation
metencephalon development
cell differentiation
neuron differentiation
forebrain development
midbrain development
somite rostral/caudal axis specification
positive regulation of embryonic development
inner ear morphogenesis
eye photoreceptor cell fate commitment
cell fate commitment
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
neuron fate commitment
neuron fate determination
diencephalon morphogenesis
anatomical structure development
primitive streak formation
positive regulation of gastrulation
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