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Proteintech
OVCA2 Polyclonal Antibody
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产品信息
14943-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
OVCA2 Fusion Protein Ag6744 (1-227 aa encoded by BC041170)
偶联物
形式
Liquid
浓度
0.17 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAAQRPLRV LCLAGFRQSE RGFREKTGAL RKALRGRAEL VCLSGPHPVP DPPGPEGARS DFGSCPPEEQ PRGWWFSEQE ADVFSALEEP AVCRGLEESL GMVAQALNRL GPFDGLLGFS QGAALAALVC ALGQAGDPRF PLPRFILLVS GFCPRGIGFK ESILQRPLSL PSLHVFGDTD KVIPSQESVQ LASQFPGAIT LTHSGGHFIP AAAPQRQAYL KFLDQFAE (1-227 aa encoded by BC041170)
靶标信息
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers. OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types.
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生物信息学
蛋白别名: candidate tumor suppressor in ovarian cancer 2; candidate tumor suppressor OVCA2; Esterase OVCA2; ortholog of human candidate tumor suppressor in ovarian cancer 2 OVCA2; ovarian cancer gene-2 protein; Ovarian cancer-associated gene 2 protein; Ovarian cancer-associated gene 2 protein homolog
基因别名: 9030414M07Rik; OVCA2; RGD1564623
UniProt ID: (Human) Q8WZ82, (Mouse) Q9D7E3
Entrez Gene ID: (Human) 124641, (Rat) 497954, (Mouse) 246257
