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GenScript
Obinutuzumab Recombinant Rabbit Monoclonal Antibody (169F10), MonoRab™
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Obinutuzumab Antibody (A01967-40) in ELISA
Standard curve of Obinutuzumab Sandwich ELISA. The Obinutuzumab Sandwich ELISA assay is developed by using MonoRab™ Anti-Obinutuzumab Antibody (8G12), mAb, Rabbit (GenScript, A01966-40) and MonoRab™ Anti-Obinutuzumab Antibody (169F10) (Genscript, A01967-40) as the capture and detection antibodies, respectively. These two antibodies recognize different epitopes. In this ELISA assay, MonoRab™ Anti-Obinutuzumab Antibody (169F10) (GenScript, A01967-40) was labeled with Biotin. GenScript can provide customized conjugation services for this prod... View More
产品信息
A01967-40
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Mammalian cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
169F10
抗原
Obinutuzumab
偶联物
形式
Lyophilized
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
Obinutuzumab (Gazyva) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of chronic lymphocytic leukemia and follicular lymphoma. It binds to a unique conformation epitope on CD20 protein, which partially overlaps with the section recognized by rituximab. When Obinutuzumab binds to CD20 on B cells, it makes these cells to be destroyed by the adaptive immune system. GenScript MonoRab™ Anti-Obinutuzumab Antibody (169F10), mAb, Rabbit is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a rabbit immunized with Obinutuzumab.
Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below.
靶标信息
Obinutuzumab is a humanized anti-CD20 monoclonal antibody, originated by GlycArt Biotechnology AG and developed by Roche as a cancer treatment. It was approved under the trade name Gazyva by the US FDA in 2013, and as Gazyvaro by the EMA in Europe, for the treatment of chronic lymphocytic leukemia in combination with chemotherapy in treatment-naive patients, and as a second line treatment for follicular lymphoma. Obinutuzumab is a fully humanized monoclonal antibody that binds to an epitope on CD20 that partially overlaps with the epitope recognized by rituximab. Obinutuzumab binds to CD20 on B cells and causes these cells to be destroyed by engaging the adaptive immune system, directly activating intracellular apoptosis pathways, and activating the complement system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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