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产品信息
PA1-75335
产品规格
种属反应
Chemical
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Oxycodone(N)-BSA
偶联物
形式
Liquid
纯化类型
purified
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1090592
产品详细信息
Working Concentration: 1/8K. Sensitivity: 10 ng/mL Oxycodone produces 39% inhibition in a competitive ELISA employing Oxycodone (N) polyclonal antibody.
靶标信息
Oxycodone is a semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. [National Center for Biotechnology Information. PubChem Compound Database; CID=5284603].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C18H21NO4; Dihydrohydroxycodeinone; Dihydrone; Dihydroxycodeinone; Oxycodeinone; Oxycontin
