Invitrogen

P-Glycoprotein Monoclonal Antibody (UIC2), Alexa Fluor™ 647

P-Glycoprotein Antibody in Flow Cytometry (Flow)

图: 1 / 1

P-Glycoprotein Antibody (MA562263) in Flow

Flow cytometry (surface staining) of P-Glycoprotein in HepG2 cells. Samples were stained with P-Glycoprotein monoclonal antibody (Product # MA562263).

Product Image Gallery

产品信息

MA562263

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

4 µL/100 µL whole blood or 10^6 cells

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

UIC2

抗原

NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA.

查看免疫原

偶联物

Alexa Fluor™ 647 Alexa Fluor™ 647 Alexa Fluor™ 647

激发/发射光谱

650/671 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Size-exclusion chromatography

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

15mM sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1

查看更多收起

基因别名: ABC20; ABCB1; CD243; CLCS; GP170; MDR1; P-GP; PGY1

查看更多收起

UniProt ID: (Human) P08183

查看更多收起

Entrez Gene ID: (Human) 5243

查看更多收起

功能

transporter activity protein binding ATP binding xenobiotic-transporting ATPase activity ATPase activity, coupled to transmembrane movement of substances ATP-binding cassette (ABC) transporter

参与通路