Invitrogen

P-Selectin Polyclonal Antibody

P-Selectin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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P-Selectin Antibody (PA5-87043) in IHC (P)

Immunohistochemistry analysis of P-Selectin in paraffin-embedded human prostate. Samples were incubated with P-Selectin polyclonal antibody (Product # PA5-87043) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

P-Selectin Antibody in Western Blot (WB)

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产品信息

PA5-87043

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Rat

已发表种属

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein of human CD62P/P-selectin.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2803797

产品详细信息

Purity is > 95% by SDS-PAGE.

靶标信息

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic stroke treatment with tPA.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Li C,Wang C,Zhang Y,Alsrouji OK,Chebl AB,Ding G,Jiang Q,Mayer SA,Lu M,Kole MK,Marin HL,Zhang L,Chopp M,Zhang ZG

PA5-87043 was used in Western Blotting to conclude that CEC-sEVs have a therapeutic effect on acute ischemic stroke by reducing neurovascular damage.

Sun Aug 01 00:00:00 UTC 2021

生物信息学

蛋白别名: CD62 antigen-like family member P; CD62P; FLJ45155; GMP-140; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; P-selectin; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; RP1-86F14.2; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet

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基因别名: CD62; CD62P; GMP140; GMRP; GRMP; LECAM3; PADGEM; PSEL; PSELECT; SELP

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UniProt ID: (Human) P16109, (Rat) P98106

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Entrez Gene ID: (Human) 6403, (Rat) 25651

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功能