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Invitrogen

P-cadherin/CD3E (Bi-specific) Recombinant Human Monoclonal Antibody (PF 6671008)

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

MA562789

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

Assay-dependent
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

功能检测 (Functional)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Human / VH-VL-VH-VL

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

PF 6671008

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Ion-exchange chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

P-cadherin a cell-cell adhesion molecule encoded by the CDH3 gene plays a critical role in maintaining tissue architecture and cellular signaling. It is significantly expressed in epithelial tissues particularly myoepithelial cells and has been associated with cancer progression and metastasis. Overexpression of P-cadherin is linked to increased cell invasion and poorer prognosis in certain cancers such as breast cancer and glioblastoma. This molecule influences cellular adhesion and proliferation and can become deregulated promoting oncogenic pathways. CD3E on the other hand encodes the epsilon chain of the CD3 complex essential in T-cell receptor signaling. It plays a vital role in the adaptive immune response facilitating antigen recognition and T-cell activation. CD3E is crucial for T-cell development and function; it interacts with other components of the immunological synapse and supports signaling cascades necessary for immune defense. Understanding the molecular interplay involving P-cadherin and CD3E can pave the way for targeted therapies in oncology and immunotherapy.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein, placental; CD3 epsilon chain; CD3-epsilon; CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CDH3; P-cadherin; Placental cadherin; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain

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基因别名: CD3E; CDH3; CDHP; HJMD; IMD18; PCAD; T3E; TCRE

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UniProt ID: (Human) P07766, (Human) P22223

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Entrez Gene ID: (Human) 916, (Human) 1001

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功能
transmembrane signaling receptor activity receptor signaling protein activity protein binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding protein heterodimerization activity molecular_function calcium ion binding cadherin
参与通路
positive regulation of T cell anergy protein complex assembly cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway response to nutrient positive regulation of gene expression negative regulation of gene expression T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-4 production positive regulation of T cell proliferation T cell activation regulation of apoptotic process negative thymic T cell selection positive regulation of interleukin-2 biosynthetic process negative regulation of smoothened signaling pathway positive regulation of alpha-beta T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response positive regulation of calcium-mediated signaling T cell receptor signaling pathway apoptotic signaling pathway retina homeostasis cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules visual perception positive regulation of keratinocyte proliferation single organismal cell-cell adhesion hair cycle process keratinization positive regulation of monophenol monooxygenase activity negative regulation of transforming growth factor beta2 production adherens junction organization wound healing response to drug positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of melanin biosynthetic process negative regulation of catagen canonical Wnt signaling pathway regulation of hair cycle by canonical Wnt signaling pathway positive regulation of melanosome transport
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