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Invitrogen
P2X6 Polyclonal Antibody
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P2X6 Antibody (PA5-87659) in WB
Western blot analysis of P2X6 in extracts of mouse pancreas. Samples were incubated with P2X6 Polyclonal antibody (Product # PA5-87659) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-87659
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human P2RX6 (NP_0011530261)
偶联物
形式
Liquid
浓度
0.47 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: WGLLDYKTEK WALLAKKGYQ ERDLEPQFSI ITKLKGVSVT QIKELGNRLW DVADFVKPPQ GENVFFLVTN FLVTPAQVQG RCPEHPSVPL ANCWVDEDCP EGEGGTHSHG VKTGQCVVFN GTHRTCEIWS WCPVESGVVP SRPLLAQAQN FTLFIKNTVT FSKFNFSKSN ALETWDPTYF KHCRYEPQFS PYCPVFRIGD LVAKAGGTFE DLALLGGSVG IRVHWDCDLD TGDSGCWPHY SFQLQEKSYN FRTATHWWEQ P; Positive Samples: Mouse pancreas; Cellular Location: Membrane, Multi-pass membrane protein
靶标信息
P2rx6 encodes receptors that are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each P2rx6 receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. The protein encoded by the P2rx6 gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. The P2rx6 gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants of P2rx6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP receptor; P2X purinoceptor 6; P2X6; P2XM; Purinergic receptor; Purinergic receptor P2X-like 1; purinergic receptor P2X-like 1, orphan receptor
基因别名: P2rx6; P2rxl1; P2x6; P2xm
UniProt ID: (Mouse) O54803
Entrez Gene ID: (Mouse) 18440
