Search

  • 联系我们
  • 货号直购

Bioss

PACAP-27/38 Polyclonal Antibody

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

产品信息

BS-0190R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:200
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human PACAP-27/38, amino acids 132-169.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

PACAP 27/38 refers to the two biologically active isoforms of pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide derived from the ADCYAP1 gene through proteolytic processing of a larger precursor protein. PACAP-38 is the predominant endogenous form, while PACAP-27 corresponds to the N-terminal 27 amino acids of PACAP-38. Both peptides function as potent signaling molecules that bind to PAC1, VPAC1, and VPAC2 receptors, activating adenylate cyclase and downstream cAMP-dependent pathways. PACAP-27/38 plays important roles in neurodevelopment, neurotransmission, neuroprotection, stress response, circadian regulation, and modulation of immune and endocrine functions. Due to their broad physiological activity and involvement in neurological, inflammatory, and metabolic disorders, PACAP isoforms are widely studied in both basic and translational research contexts.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: adenylate cyclase activating polypeptide 1 (pituitary); PACAP; PACAP 27; PACAP 28; pituitary adenylate cyclase activating polypeptide 1; Pituitary adenylate cyclase-activating polypeptide; pituitary adenylate cyclase-activating polypeptide precursor (Pacap); prepro-PACAP; unnamed protein product

查看更多 收起

基因别名: ADCYAP1; PACAP

查看更多 收起

UniProt ID: (Human) P18509, (Rat) P13589, (Mouse) O70176

查看更多 收起

Entrez Gene ID: (Human) 116, (Rat) 24166, (Mouse) 11516

查看更多 收起

功能
receptor binding hormone activity neuropeptide hormone activity protein binding pituitary adenylate cyclase activating polypeptide activity type 1 vasoactive intestinal polypeptide receptor binding type 2 vasoactive intestinal polypeptide receptor binding peptide hormone receptor binding receptor signaling protein activity pituitary adenylate cyclase-activating polypeptide receptor binding neuropeptide
参与通路
adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway cell-cell signaling nervous system development female pregnancy regulation of G-protein coupled receptor protein signaling pathway positive regulation of gene expression insulin secretion neuron projection development regulation of protein localization positive regulation of GTPase activity negative regulation of cell cycle positive regulation of protein kinase activity positive regulation of transcription from RNA polymerase II promoter positive regulation of growth hormone secretion positive regulation of ERK1 and ERK2 cascade positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of cold-induced thermogenesis positive regulation of cAMP/PKA signal transduction ovarian follicle development behavioral fear response histamine secretion negative regulation of acute inflammatory response to antigenic stimulus negative regulation of acute inflammatory response to non-antigenic stimulus positive regulation of cell proliferation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway negative regulation of muscle cell apoptotic process positive regulation of neuron projection development sensory perception of pain cAMP-mediated signaling pituitary gland development positive regulation of cAMP biosynthetic process positive regulation of interleukin-6 production negative regulation of GTPase activity intracellular signal transduction response to starvation negative regulation of potassium ion transport response to ethanol positive regulation of vasodilation ATP metabolic process positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential negative regulation of glial cell proliferation regulation of oligodendrocyte progenitor proliferation cellular response to glucocorticoid stimulus positive regulation of somatostatin secretion
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持