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Proteintech
PAK6 Polyclonal Antibody
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产品信息
13539-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PAK6 Fusion Protein Ag4467 (330-681 aa encoded by BC035596)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody has weak cross-reaction with other PAK members.
Immunogen sequence: QKSLRTAPA TGQLPGRSSP AGSPRTWHAQ ISTSNLYLPQ DPTVAKGALA GEDTGVVTHE QFKAALRMVV DQGDPRLLLD SYVKIGEGST GIVCLAREKH SGRQVAVKMM DLRKQQRREL LFNEVVIMRD YQHFNVVEMY KSYLVGEELW VLMEFLQGGA LTDIVSQVRL NEEQIATVCE AVLQALAYLH AQGVIHRDIK SDSILLTLDG RVKLSDFGFC AQISKDVPKR KSLVGTPYWM APEVISRSLY ATEVDIWSLG IMVIEMVDGE PPYFSDSPVQ AMKRLRDSPP PKLKNSHKVS PVLRDFLERM LVRDPQERAT AQELLDHPFL LQTGLPECLV PLIQLYRKQT STC (330-681 aa encoded by BC035596)
靶标信息
PAK6 is a serine/threonine kinase expressed in the testis and prostate. It associates with both the estrogen and androgen receptors. The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: p21 (CDKN1A)-activated kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; PAK-5; PAK-6; Serine/threonine-protein kinase PAK 6
基因别名: 4732456M09; PAK5; PAK6
UniProt ID: (Human) Q9NQU5, (Mouse) Q3ULB5
Entrez Gene ID: (Human) 56924, (Mouse) 214230, (Rat) 296078
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
cadherin binding involved in cell-cell adhesion
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Rac GTPase binding
regulation of transcription, DNA-templated
protein phosphorylation
Rho protein signal transduction
regulation of mitotic cell cycle
learning
memory
locomotory behavior
phosphorylation
cell migration
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
regulation of MAPK cascade
mitotic cell cycle
apoptotic process
cytoskeleton organization
cell-cell adhesion
intracellular signal transduction
