Invitrogen

PAR1 Polyclonal Antibody

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PAR1 Polyclonal Antibody

产品信息

PA5-94929

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL
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免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL
-
产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence at the N-terminus of human Thrombin Receptor (46-82aa RNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQK).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2806735

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: MCF-7 whole cell, HELA whole cell, 22RV1 whole cell, SW620 whole cell. IHC: Human Placenta Tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface G-protein coupled receptors which include PAR-1, PAR-2 and PAR3.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: C HTR; coagulation factor II (thrombin) receptor; Coagulation factor II receptor; PAR-1; protease activated receptor 1; protease-activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor

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基因别名: CF2R; F2R; HTR; PAR-1; PAR1; TR

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UniProt ID: (Human) P25116

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Entrez Gene ID: (Human) 2149

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功能
G-protein alpha-subunit binding G-protein coupled receptor activity receptor binding protein binding thrombin receptor activity G-protein beta-subunit binding G-protein coupled receptor
参与通路
activation of MAPKK activity connective tissue replacement involved in inflammatory response wound healing negative regulation of glomerular filtration activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway tyrosine phosphorylation of STAT protein STAT protein import into nucleus establishment of synaptic specificity at neuromuscular junction blood coagulation positive regulation of cell proliferation negative regulation of cell proliferation response to wounding anatomical structure morphogenesis positive regulation of phosphatidylinositol 3-kinase signaling platelet activation regulation of blood coagulation positive regulation of blood coagulation positive regulation of cell migration response to lipopolysaccharide regulation of interleukin-1 beta production positive regulation of collagen biosynthetic process positive regulation of Rho protein signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of vasoconstriction positive regulation of smooth muscle contraction positive regulation of JAK-STAT cascade homeostasis of number of cells within a tissue release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of calcium ion transport regulation of sensory perception of pain platelet dense granule organization positive regulation of ERK1 and ERK2 cascade thrombin receptor signaling pathway negative regulation of renin secretion into blood stream positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion
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