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Invitrogen
PAR4 Polyclonal Antibody
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产品信息
PA1-28227
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the Human C terminal region.
偶联物
形式
Liquid
保存条件
4°C, do not freeze
运输条件
Wet ice
RRID
产品详细信息
PA1-28227 detects PAR4 from human, mouse, rat samples.
PA1-28227 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-28227 immunogen is: Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) C-terminal (Human).
靶标信息
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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