Invitrogen

PARP1 Polyclonal Antibody

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3 篇参考文献
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说明书
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问题与答案
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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
PARP1 Polyclonal Antibody

产品信息

PA3-951

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1000
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免疫细胞化学 (ICC/IF)

-
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酶联免疫吸附实验 (ELISA)

Assay-dependent
-

亲和纯化 (AP)

-
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产品规格

种属反应

Bovine, Human, Mouse, Rat

已发表种属

C. elegans, Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to aa 509-524 of bovine PARP auto modification domain.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

whole serum

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2160723

产品详细信息

By Western blot, this antibody detects a 116 kDa protein representing PARP and the 85 kDa apoptosis-induced cleavage product of protease resembling ICE (prICE) and CPP32 from GH4C1 cell extract.

靶标信息

Poly ADP-Ribose Polymerase (PARP) uses nicotinamide adenine dinucleotide (oxidized form) NAD as a substrate to catalyse the transfer of ADP-ribose to a variety of nuclear protein acceptors. Proteolysis of PARP to its stable 85kDa fragment is an early marker of programmed cell death (apoptosis) and is mediated by the caspase CPP32 protein. Cleavage occurs between Adp216 and Gly217, a site in PARP conserved across species.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase); ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT 1; ARTD1; DNA ADP-ribosyltransferase PARP1; msPARP; NAD(+) ADP-ribosyltransferase 1; NAD(+) pADPRT-1; PARP-1; poly (ADP-ribose) polymerase 1; poly (ADP-ribose) polymerase family, member 1; poly (ADP-ribose) polymerase); Poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) polymerase PARP-1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; Poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; Protein poly-ADP-ribosyltransferase PARP1; unnamed protein product

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基因别名: 5830444G22Rik; Adprp; ADPRT; ADPRT 1; ADPRT1; AI893648; ARTD1; C80510; pADPRT-1; PARP; PARP-1; PARP1; PPOL; sPARP-1

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UniProt ID: (Bovine) P18493, (Human) P09874, (Rat) P27008

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Entrez Gene ID: (Bovine) 286764, (Human) 142, (Rat) 25591, (Mouse) 11545

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功能
DNA binding zinc ion binding NAD binding protein ADP-ribosylase activity DNA ligase (ATP) activity NAD+ ADP-ribosyltransferase activity protein binding transcription factor binding enzyme binding protein kinase binding identical protein binding histone deacetylase binding poly(A) RNA binding protein N-terminus binding R-SMAD binding transferase activity, transferring pentosyl groups chromatin binding transferase activity transferase activity, transferring glycosyl groups metal ion binding DNA metabolism protein
参与通路
double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus positive regulation of cardiac muscle hypertrophy peptidyl-serine ADP-ribosylation peptidyl-glutamic acid poly-ADP-ribosylation DNA ADP-ribosylation protein poly-ADP-ribosylation protein auto-ADP-ribosylation positive regulation of double-strand break repair via homologous recombination ATP generation from poly-ADP-D-ribose negative regulation of transcription from RNA polymerase II promoter nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding double-strand break repair via homologous recombination lagging strand elongation DNA repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion transcription from RNA polymerase II promoter mitochondrion organization transforming growth factor beta receptor signaling pathway protein autoprocessing protein sumoylation signal transduction involved in regulation of gene expression macrophage differentiation mitochondrial DNA metabolic process cellular response to insulin stimulus nucleotide-excision repair, DNA incision cellular response to oxidative stress protein modification process DNA damage response, detection of DNA damage mitochondrial DNA repair positive regulation of transcription from RNA polymerase II promoter DNA ligation involved in DNA repair positive regulation of SMAD protein import into nucleus global genome nucleotide-excision repair regulation of cellular protein localization negative regulation of telomere maintenance via telomere lengthening positive regulation of transcription regulatory region DNA binding telomere maintenance DNA metabolic process base-excision repair transcription, DNA-templated regulation of growth rate cellular response to superoxide regulation of transcription, DNA-templated behavioral response to cocaine regulation of single strand break repair
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