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Bethyl Laboratories
PARP12 Polyclonal Antibody
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PARP12 Antibody (A305-130A) in WB
Detection of human and mouse PARP12 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-PARP12 antibody (Product # A305-130A) (lot A305-130A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 1 second.
产品信息
A305-130A
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 300 to 350 of human Poly [ADP-ribose] polymerase 12.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADP-ribosyltransferase diphtheria toxin-like 12; ARTD12; PARP-12; poly (ADP-ribose) polymerase family, member 12; Poly [ADP-ribose] polymerase 12; poly ADP-ribose polymerase 12; Protein mono-ADP-ribosyltransferase PARP12; Zinc finger CCCH domain-containing protein 1; zinc finger CCCH type domain containing 1
基因别名: 9930021O16; AA409132; AA536654; ARTD12; MST109; MSTP109; PARP-12; PARP12; ZC3H1; ZC3HDC1
UniProt ID: (Human) Q9H0J9, (Mouse) Q8BZ20
Entrez Gene ID: (Human) 64761, (Mouse) 243771
