Sequence homology: Cow: 79%; Dog: 86%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 80%; Rabbit: 86%; Rat: 86%
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
蛋白别名: ADP-ribosyltransferase diphtheria toxin-like 15; PARP-16; poly (ADP-ribose) polymerase family, member 16; Poly [ADP-ribose] polymerase 16; Protein mono-ADP-ribosyltransferase PARP16
基因别名: ARTD15; C15orf30; PARP16; pART15
UniProt ID: (Human) Q8N5Y8
Entrez Gene ID: (Human) 54956