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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
0.2-1 µg/mL | - |
免疫组化 (IHC) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide located within the following region: KLPLSRLKFM HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Affinity Chromatography |
保存液 |
PBS, pH 7.4, with 2% sucrose |
内含物 |
0.09% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2817925 |
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; PARP-6; poly (ADP-ribose) polymerase family, member 6; Poly [ADP-ribose] polymerase 6; Protein mono-ADP-ribosyltransferase PARP6
基因别名: ARTD17; PARP-6-B1; PARP-6-C; PARP6; pART17
UniProt ID: (Human) Q2NL67
Entrez Gene ID: (Human) 56965
