Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
蛋白别名: ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; PARP-6; poly (ADP-ribose) polymerase family, member 6; Poly [ADP-ribose] polymerase 6; Protein mono-ADP-ribosyltransferase PARP6
基因别名: ARTD17; PARP-6-B1; PARP-6-C; PARP6; pART17
UniProt ID: (Human) Q2NL67
Entrez Gene ID: (Human) 56965