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Invitrogen
PAX5 Recombinant Rabbit Monoclonal Antibody (RM331)
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PAX5 Antibody (MA5-33084) in IHC (P)
Immunohistochemical analysis of PAX5 was performed using formalin-fixed paraffin-embedded human lymph node tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minutes. ... View More
产品信息
MA5-33084
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM331
抗原
A peptide corresponding to C-terminus of human Paired box protein Pax-5.
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: reacts to human Paired box protein Pax-5. It may also react to mouse Paired box protein Pax-5, as predicted by immunogen homology.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
PAX5 is a member of the paired box (PAX) family of transcription factors. The PAX proteins are important regulators in early development and alterations in the expression of their genes are thought to contribute to neoplastic transformation. PAX5 is the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages, of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. Mutations in the gene can result in leukemia, acute lymphoblastic 3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; paired box homeotic gene 5; Paired box protein Pax-5; paired domain gene 5; transcription factor PAX 5
基因别名: ALL3; BSAP; PAX5
UniProt ID: (Human) Q02548
Entrez Gene ID: (Human) 5079
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
humoral immune response
multicellular organism development
spermatogenesis
aging
organ morphogenesis
lateral ventricle development
cerebral cortex development
adult behavior
skeletal muscle cell differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic cranial skeleton morphogenesis
negative regulation of histone H3-K9 methylation
