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Invitrogen
PCAF Polyclonal Antibody
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产品信息
PA1-25467
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, conjugated to KLH, corresponding to residues E(817) K F F F S K I K E A G L I D K(832) of human PCAF, with an N-terminal added cyst
偶联物
形式
Liquid
浓度
1.25 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-25467 detects PCAF from human and canine samples and is expected to cross react with mouse and chicken due to sequence homology.
PA1-25467 has been successfully used in Western blot and immunoprecipitation procedures.
The PA1-25467 immunogen is a synthetic peptide, conjugated to KLH, corresponding to residues E(817) K F F F S K I K E A G L I D K(832) of human PCAF, with an N-terminal added cysteine.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
靶标信息
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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