Invitrogen

PCBP4 Polyclonal Antibody

产品信息

PA5-50704

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:200-1:1,000	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide corresponding to residues near the C terminal of human poly(rC) binding protein 4 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1.9 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2636156

产品详细信息

The antibody detects endogenous levels of total MCG10 protein.

靶标信息

MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。