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Recommended positive controls: U87-MG, SK-N-SH.
Predicted reactivity: Rat (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: KIAA0345-like 4; ortholog to mouse CNR8; PCDH-alpha-10; Protocadherin alpha-10
基因别名: CNR8; CNRN8; CNRS8; CRNR8; PCDH-ALPHA10; PCDHA10
UniProt ID: (Human) Q9Y5I2
Entrez Gene ID: (Human) 56139
分子生物学功能: cadherin