Search Thermo Fisher Scientific
Peptide Sequence: SGTSRICVKV LDANDNAPVF TQPEYRISIP ENTLVGTRIL TVTATDADEG YYAQVVYFLE KSPGETSEVF ELKSTSGELT IIKDLDYEDA TFHEIDIEAQ DGPGLLTRA
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: PCDH-gamma-A2; Protocadherin gamma-A2
基因别名: mKIAA0588; PCDH-GAMMA-A2; PCDHGA2
UniProt ID: (Human) Q9Y5H1
Entrez Gene ID: (Human) 56113, (Mouse) 93710
分子生物学功能: cadherin