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PCGF1 Antibody (PA5-49390) in WB
Western blot analysis of PCGF1 in lysates from human brain, mouse brain, mouse cerebellum, rat brain tissue (from left to right). Samples were incubated with PCGF1 polyclonal antibody (Product # PA5-49390) using a dilution of 1:1,000 followed by goat anti-rabbit IgG H&L (HRP) at a dilution of 1:10,000. Lysates at 20 µg per lane.
产品信息
PA5-49390
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 117-151 amino acids from the Central region of human PCGF1.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2634844
产品详细信息
Predicted to react with bovine based on sequence homology.
靶标信息
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: nervous system polycomb 1; Nervous system Polycomb-1; NSPc1; Polycomb group RING finger protein 1; RING finger protein 68
基因别名: 2010002K04Rik; AU024121; NSPC1; PCGF1; RNF3A-2; RNF68
UniProt ID: (Human) Q9BSM1, (Mouse) Q8R023, (Rat) Q6DLV9
Entrez Gene ID: (Human) 84759, (Mouse) 69837, (Rat) 312480
