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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation. PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger. PCGF6 acts as a transcriptional repressor and regulates the level of histone H3K4Me3 by activating SmcY histone demethylase. PCGF6 exists as two alternatively spliced isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Mel18 and Bmi1-like RING finger; Mel18 and Bmi1-like RING finger protein; Mel18- and Bmi1-like RING finger protein; Polycomb group RING finger protein 6; RING finger protein 134
基因别名: 4933407A11Rik; AI604840; MBLR; PCGF6; RNF134
UniProt ID: (Human) Q9BYE7, (Mouse) Q99NA9
Entrez Gene ID: (Human) 84108, (Mouse) 71041
分子生物学功能:
histone modifying enzyme
