Display Info New header:
tfpt-header-footer.tfcom-eks-na-comerce-gateway-prd.commerceprod.thermofisher.net cookie.CK_ISO_CODE.value:cn
cookie.CK_LANG_CODE.value:zh
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@48ca8c4e
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType:/anonymous enableSimpleHeaderValue:

Invitrogen

PCNA Monoclonal Antibody (PC10), PE

查看其他82个PCNA抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

MA562391

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

10 µL/100 µL whole blood or 10^6 cells
-
产品规格

种属反应

Chicken, Fruit fly, Human, Mouse, Non-human primate, Rat

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

PC10

抗原

Recombinant rat PCNA.

偶联物

PE PE PE

激发/发射光谱

565/576 nm 查看光谱 spectra

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Size-exclusion chromatography

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

15mM sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: CG9193-PA; CG9193-PB; Cyclin; DNA polymerase delta auxiliary protein; HGCN8729; LD45889p; MGC8367; mutagen-sensitive 209; Mutagen-sensitive 209 protein; PCNA; PCNA-PA; PCNA-PB; Proliferating cell nuclear antigen; proliferating-cell nuclear antigen; Proliferating-cell-nuclear-antigen

查看更多 收起

基因别名: 53/13; ATLD2; CG9193; Dmel\CG9193; Dmel_CG9193; DmPCNA; DmPCNA1; dPCNA; l(2)02448; l(2)56F; l(2)56Fa; l(2)s1534; mus 209; MUS209; PCNA; Pcna/cyclin; PCNA/mus209; PCNA1; PCNAR

查看更多 收起

UniProt ID: (Fruit fly) P17917, (Human) P12004, (Chicken) Q9DEA3, (Rat) P04961, (Mouse) P17918

查看更多 收起

Entrez Gene ID: (Fruit fly) 37290, (Human) 5111, (Chicken) 373984, (Rat) 25737, (Mouse) 18538

查看更多 收起

功能
DNA binding chromatin binding DNA polymerase processivity factor activity purine-specific mismatch base pair DNA N-glycosylase activity damaged DNA binding protein binding enzyme binding estrogen receptor binding receptor tyrosine kinase binding dinucleotide insertion or deletion binding MutLalpha complex binding histone acetyltransferase binding identical protein binding DNA polymerase binding protein C-terminus binding transcription factor binding DNA polymerase processivity factor
参与通路
DNA replication DNA-dependent DNA replication leading strand elongation regulation of DNA replication nucleotide-excision repair mismatch repair cellular response to DNA damage stimulus mitotic spindle organization eggshell chorion gene amplification response to UV translesion synthesis response to hydrogen peroxide response to methyl methanesulfonate G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle telomere maintenance via recombination telomere maintenance DNA strand elongation involved in DNA replication transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest heart development cell proliferation protein sumoylation epithelial cell differentiation replication fork processing positive regulation of deoxyribonuclease activity nucleotide-excision repair, DNA incision response to lipid cellular response to UV error-prone translesion synthesis DNA damage response, detection of DNA damage positive regulation of DNA repair positive regulation of DNA replication response to cadmium ion error-free translesion synthesis mitotic telomere maintenance via semi-conservative replication negative regulation of transcription from RNA polymerase II promoter DNA repair base-excision repair, gap-filling cellular response to xenobiotic stimulus positive regulation of DNA-directed DNA polymerase activity regulation of catalytic activity
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持
Display Info:
cookie.CK_ISO_CODE.value:cn
cookie.CK_LANG_CODE.value:zh
cookie.CK_DISPLAY_TYPE.value:
pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType:/anonymous